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Biochemistry, Biophysics and Bioinformatics

M  K  M A T H E W
RESEARCH I LAB MEMBERS I PUBLICATIONS

 

PUBLICATIONS AND THESES

 

Ramaswami M, Tanouye MA & Mathew MK (1994) Ind. J. Biochem. Biophys. 31, 254-260. Facile formation of heteromultimeric potassium channels by expression of cloned human cDNAs .

Ramu YD, Nallathambi T & Mathew MK (1996) Current Science 70, 313 - 315 Comparative studies on the radula teeth of two species of Conus from the Indian coast

Seth S, Balaram P and Mathew MK (1997) Helix-sheet interconversion in a synthetic pore-lining peptide derived from a designed ion channel Curr. Sci. 72(7): 509-512.

Seth S, Balaram P and Mathew MK (1997) Characterization of a 22-residue peptide derived from a designed ion channel Biochim. Biophys. Acta 1328, 177 - 184

Mathew MK (1997) Fluorescence Resonance Energy Transfer J. Indian Soc Radiation Photochem Sci 8, 20-25.

Jayaprakash TL, Ramammohan G, Krishnaprasad BT, Ganesh Kumar, Prasad TG, Mathew MK & Udayakumar M (1998) Genotypic Variability in Differential Expression of lea2 and lea3 Genes and Proteins in Response to Salinity Stress in Fingermillet (Eleusine coracana Gaertn) and Rice (Oryza sativa L.) Seedlings Annals of Botany 82: 513 - 522

Chanda B & Mathew MK (1999) Functional Reconstitution of Bacterially Expressed Potassium Channels in Proteoliposomes : Membrane Potential Measurements with JC-1 to Assay Ion Channel Activity . Biochim. Biophys. Acta 1416: 92 - 100

Chanda B, Tiwari JK, Varshney A & Mathew MK (1999) Transplanting N-termini from hKv1.4 to hKv1.1 generates an inwardly rectifying K+ channel. NeuroReport 10: 237 - 241

Chanda B, Tiwari JK, Varshney A & Mathew MK (1999) Exploring the Architecture of Potassium Channels Using Chimeras To Reveal Signal Transduction Biosci Reports 9 (4): 301-306

RajGanesh PS, Chanda B, Gupta SK, Mathew MK & Chandraseakhar J (2000) Modeling of ion permeation in calcium and sodium channel selectivity filters Proteins: Structure, Function and Genetics 38: 384 - 392

Varshney A & Mathew MK (2000) Cytoplasmic residues influence voltage-dependent gating in human potassium channels . NeuroReport 13 (11): 2913 - 2917

Bhuyan A, Varshney A, Mathew MK (2001) Resting Membrane Potential as a Marker of Apoptosis: Studies on Xenopus oocytes microinjected with cytochrome c. Cell Death & Differentiation 8: 63 – 69

Gopalakrishna R, Ganesh Kumar, KrishnaPrasad BT, Mathew MK, and Udaya kumar M (2001) A Stress Responsive Gene from Groundnut, Gdi-15, Is Homologous to Flavonol 3-O-Glucosyltransferase Involved in Anthocyanin Biosynthesis . Biochem. Biophys. Res. Commun. 284, 574–579

Varshney A, Kavitha S & Mathew MK (2002) Modulation of Voltage Sensitivity by N-terminal Cytoplasmic Residues in Human Kv1.2 Channels Eur Biophys J 31, 365 – 72

Varshney A. & Mathew MK (2003) Inward and Outward Potassium Currents Through the Same Chimæric Human Kv Channel Eur Biophys J 32, 113 - 121

Dhawan R , Varshney A, Mathew MK & Lala AK (2003) BTK-2, A New Inhibitor of the Kv1.1 Potassium Channel Purified from Indian Scorpion Buthus Tamulus FEBS Letts 539, 7 – 13

 Varshney A & Mathew MK (2003) A Tale of Two Tails: Cytoplasmic Termini and K+ channel function Progr. Biophys. Mol. Biol. 83, 153 - 170

Godbole A, Varghese J, Sarin A & Mathew MK (2003) VDAC is a conserved element of death pathways in plant and animal systems Biochim. Biophys. Acta 1642, 87 – 96.

Varshney A, Chanda B & Mathew MK (2004) Arranging the elements of the potassium channel: The T1 domain occludes the cytoplasmic face of the channel Eur Biophys J 33, 370 – 376

Sade H, Khandre NS, Mathew MK & Sarin A (2004) The mitochondrial phase of the glucocorticoidinduced
apoptotic response in thymocytes comprises sequential activation of adenine nucleotide transporter (ANT)-independent and ANTdependent events
Eur. J. Immunol 34, 119 - 125

Varshney A & Mathew MK (2004) Architecture of a membrane protein: The voltage-gated K+ channel   Current Science 87, 166 - 174

Srikanth S, Wang Z, Tu H, Nair S, Mathew MK, Hasan G & Bezprozvanny I (2004) Functional Properties of the Drosophila melanogaster Inositol 1,4,5-Trisphosphate Receptor Mutants Biophys J 86, 3634–3646

VS Anil, P Krishnamurthy, S Kuruvilla, Sucharitha K, G Thomas & MK Mathew (2005) Regulation of the uptake and distribution of Na+ in shoots of rice (Oryza sativa L.) variety Pokkali: Role of Ca2+ in salt tolerance response Physiol. Plantarum 124, 451 - 464

Kavitha S, Varshney A & Mathew MK (2005) N type rapid inactivation in human Kv1.4 channels: Functional role of a putative C- terminal helix Molec. Membr. Biol. 22, 389 – 400

N. Sundara Baalaji, M.K. Mathew, S. Krishnaswamy (2006) Functional assay of S.typhi OmpC using reconstituted large unilamellar vesicles: A general method for characterization of outer membrane proteins Biochimie 88, 1419–1424

Anil V, Krishnamurthy H & Mathew MK (2007) Limiting Cytosolic Na+ Confers Salt Tolerance to Rice Cells in Culture: A Two-Photon Microscopy Study of SBFI Loaded Cells Physiol Plantarum 129, 607 – 621

Anil V, Krishnamurthy H & Mathew MK (2007) Na+ Efflux Across the Plasma Membrane Contributes to Salt Tolerance of Rice Cells in Culture Proceedings Indian National Science Academy 73, 43 – 50

Anil A, Premraj R, Kumar P & Mathew MK (2008) A Plant Ca-Pump, Aca2, Relieves Salt Hypersensitivity In Yeast: Modulation Of Cytosolic Calcium Signature And Activation Of Adaptive Na+ Homeostasis J Biol Chem 283, 3497-3506

Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay S, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M & Hamza I (2008) Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins Nature in press

Kavitha, S., Usman, H. and Mathew, M.K. (2009). Fast inactivation in potassium channels – interplay of multiple cytoplasmic domains. Biochem Biophys Research Communication, 388, 490–495.

Krishnamurthy, P., Ranathunge, K., Franke, R., Prakash, H.S., Schreiber, L. and Mathew, M.K. (2009) Salt tolerance in rice (Oryza sativa L.): Role of apoplast forming barriers in the roots. Planta, 230, 119–134.

Upadhyay, S.K., Nagarajan, P. and Mathew, M.K. (2009). Potassium channel opening: A subtle two step . Journal of  Physiology, 587, 3851–3868.

Usman, H., Kumari, S. and Mathew, M.K. (2010). Tumor suppressor candidate KCNRG   regulates surface expression of Shaker type potassium channels Biochem Biophys Res. Commun 391, 1301–1305.

Kumar GS, Upadhyay S, Mathew MK, Sarma SP (2011). Solution structure of BTK-2, a novel hK(v)1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulus. Biochim Biophys Acta. 2011 Apr;1814(4):459-69. Epub 2011 Jan 21.

Shrivastava R, Basu B, Godbole A, Mathew MK, Apte SK, Phale PS. Repression of the glucose-inducible outer-membrane protein OprB during utilization of aromatic compounds and organic acids in Pseudomonas putida CSV86. Microbiology. 2011 May;157(Pt 5):1531-40. Epub 2011 Feb 17.

Krishnamurthy P, Ranathunge K, Nayak S, Schreiber L, Mathew MK. Root apoplastic barriers block Na+ transport to shoots in rice (Oryza sativa L.). J Exp Bot. 2011 Aug;62(12):4215-28. Epub 2011 May 9.

Godbole A, Mitra R, Dubey AK, Reddy PS, Mathew MK. Bacterial expression, purification and characterization of a rice voltage-dependent, anion-selective channel isoform, OsVDAC4. J Membr Biol. 2011 Nov;244(2):67-80.  Epub 2011 Nov 6.

 

Theses:

S SETT: Design and Characterization of Synthetic Ion Channels Awarded PhD degree by Bombay University in 1998

B CHANDA: Expression, Characterisation and Structure-Function Studies on Human Potassium Channels Awarded PhD degree by Mysore University in 2000

PS RAJGANESH: Modeling of Ion Permeation in Calcium and Sodium Channel Selectivity Filters Awarded MSc in Engineering by Indian Institute of Science in 1999

R ISSAAC: Characterisation of a Fraction from the Scorpion Heterometrus fulvipes Venom that Blocks an Inactivating Voltage Gated Human Potassium Channel Awarded MSc degree by the Manipal Academy of Higher Education (MAHE), 2000

R GOPALKRISHNA: Cloning and Characterization of Moisture Stress Responsive Genes from Stress Tolerant Crop Groundnut (Arachis hypogaea L.). Awarded PhD degree by University of Agricultural Sciences, Bangalore, in 2001.

A VARSHNEY: The role of Cytoplasmic Residues in Human Potassium Channels: An Investigation Using Chimæric Channels. Awarded PhD by MAHE in 2003.

A GODBOLE: Functional Characterization of VDAC: A Conserved Element of Programmed Cell Death Pathways. Awarded PhD by MAHE in 2005

S KAVITHA:  Role of Cytoplasmic Residues in Modulating Voltage-Gated Potassium Channel Function. Awarded PhD by TIFR in 2007