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GFP::RAB-3 accumulates at cut ends of mechanosensory neuron 1 hr post-axotomy Scale bar 10 um

Images by Sucheta Kulkarni

MEETING REPORTS

Research Publications:

• Mondal S.*, Ahlawat S., Koushika S. P.*, Simple Microfluidic Devices for in vivo Imaging of C. elegans, Drosophila and Zebrafish. JoVE (67), e3780, DOI: 10.3791/3780 (2012)
  
  

• Monteiro MI, Ahlawat S, Kowalski JR, Malkin E, Koushika S. P., Juo P., The kinesin-3 family motor KLP-4 regulates anterograde trafficking of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans. Molecular Biology of the Cell. 2012 Sep;23(18):3647-62. Epub 2012 Aug 1.
  
  

• Fatouros C, Pir GJ, Biernat J, Koushika S.P., Mandelkow E, Mandelkow EM, Schmidt E, Baumeister R., Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity. Human Molecular Genetics, 2012 Aug, 15; 21(16): 3587-603. Epub 2012 May 18
  
  

• Surana, S., Bhat, J. M., Koushika, S. P.* and Krishnan, Y.*, An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism. Nature Communications, 2011 June 7. 2 : 340 doi: 10.1038/ncomms1340.
  
  *Indicates co-corresponding authors.
  
  

• Maniar T., Kaplan M., Wang G. J., Shen K., Wei L., Starich T., Shaw J.E., Koushika S. P., Bargmann C. I.  Neuronal microtubule organization and polarized axon-dendrite protein sorting are directed by unc-33/CRMP and unc-44/ankyrin. Nature Neuroscience, 2011, 15(1):48-56. doi: 10.1038/nn.2970
  
  Featured in ‘News & Views’ of Nature Neuroscience, 15(1):7-8. doi: 10.1038/nn.3015
  
  

• Bhatia, D., Surana, S., Chakraborty, S., Koushika, S. P. and Krishnan, Y., A synthetic, icosahedral DNA-based host-cargo complex for functional in vivo imaging. Nature Communications, 2011 June 7. 2 : 339 doi: 10.1038/ncomms1337
  
  
  
• Mondal S., Ahlawat S., Rau K., Venkatraman V., Koushika S. P.*, Imaging in vivo neuronal transport in genetic model organisms using microfluidic devices. Traffic. 2010 Dec 30. doi: 10.1111/j.1600-0854.2010.01157.x. [Epub ahead of print]
  
  Recommended by Faculty of 1000 http://f1000.com/8306956
  
  
  
• Arimoto M., Koushika S. P., Choudhary B. C., Li C., Matsumoto N., Hisamoto N., The C. elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 to cytoplasmic dynein.  Journal of Neuroscience, 2011, Vol. 31 No. 6: pages 2216-24.
  
  

• Kumar J., Choudhary B. C., Metpally R., Zheng Q., Nonet M. L., Ramanathan S., Klopfenstein D. R., Koushika S. P.*, The Caenorhabditis elegans Kinesin-3 motor UNC-104/KIF1A is degraded upon loss of specific binding to cargo. PLoS Genetics, 2010 Nov 4;6(11):e1001200
  
  
  
• Murthy K., Bhat J. M., Koushika S. P.*, In vivo imaging of retrogradely transported synaptic vesicle proteins in Caenorhabditis elegans neurons. Traffic, 2010 Oct 4. doi: 10.1111/j.1600-0854.2010.01127.x. [Epub ahead of print]
  
  
  
• Rao N. G., Kulkarni S. S., Koushika S. P.*, Rau K. R.*,  In vivo Nanosecond laser axotomy: cavitation dynamics and vesicle transport , Optics Express, Vol. 16, No. 13, 9884-9894 (2008).
  
  *Indicates co-corresponding authors.
  
  
  
• Koushika S. P.*, "JIP"ing along the axon: the complex roles of JIPs in axonal transport , Bioessays, Vol. 30, No. 1, 10-14 (2008).

Papers from my post-doctoral and Ph.D. research

• Koushika S.P.*, Schaefer A. M., Vincent R., Willis J., Bowerman B., Nonet M. L.*, Mutations in C. elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo , Journal of Neuroscience, Vol. 24, No. 16, 3907-3916 (2004).
  
  *Indicates co-corresponding authors.
  
  Featured in ‘This week in the Journal’ of Journal of Neuroscience, Vol.24, No. 16.
  
  Recommended by Faculty of 1000 http://f1000.com/1018696
  
  

• Simmer F, Tijsterman M, Parrish S, Koushika S.P., Nonet M. L., Fire A, Ahringer J, Plasterk R. H. A., Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi , Current Biology, Vol.12, No.15, 1317-3139 (2002).
  
  Recommended by Faculty of 1000 http://f1000.com/1008960
  

• Toba G., Qui J., Koushika S. P., White K., Ectopic expression of Drosophila ELAV and human HuD Drosophila wing in Drosophila wing disc cells reveals functional distinctions and similarities , Journal of Cell Sciences, Vol. 115, 2413-2421 (2002)
  
  

• Koushika S. P.^#, Richmond J. E.^#, Hadwiger G., Weimer R. M., Jorgensen E. M., Nonet M. L., A post-docking role for active zone protein Rim , Nature Neuroscience, Vol. 4, No.10, 997-1005 (2001).
  
  ^#Indicates equal contribution.
  
  Featured in ‘News & Views’ of Nature Neuroscience, Vol. 4, No. 10.
  
  Recommended by Faculty of 1000 http://f1000.com/1001031
  

• Koushika S. P.*, Nonet M. L.*, Sorting and transport in C. elegans: a model system with a sequenced genome , Current Opinion in Cell Biology, Vol. 12, No. 4, 517-523 (2000).
  
  *Indicates co-corresponding authors.
  
  
  
• Koushika S. P.^#, Soller M.^#, White K, Neuron-enriched splicing pattern of Drosophila erect wing is dependent on the presence of ELAV protein , Molecular and Cellular Biology, Vol. 20, No. 5, 1836-1845 (2000).
  
  ^#Indicates equal contribution.
  
  

• Koushika S. P., Soller M., DeSimone S. M., Daub D. M., White K., Differential and inefficient splicing of a broadly expressed Drosophila erect wing transcript results in tissue-specific enrichment of the vital EWG protein isoform , Molecular and Cellular Biology, Vol. 19, No.6, 3998-4007 (1999).
  
  

• Koushika S. P., Lisbin M. J., White K., ELAV a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protien isoform , Current Biology, Vol. 6, No. 12, 1634-1641 (1996).