Prof. Satyajit Mayor - Archive Publications

Archive - Research Articles

2016-19

57. Kim S, Kalappurakkal JM, Mayor S, Rosen MK. Phosphorylation of Nephrin induces phase separated domains that move through actomyosin contraction. Mol Biol Cell. 2019 Oct 10:mbcE18120823. doi: 10.1091/mbc.E18-12-0823. PubMed PMID: 31599693. (biorXiv preprint can be accessed here)
56. Sil P, Mateos N, Nath S, Buschow S, Manzo C, Suzuki KGN, Fujiwara T, Kusumi A, Garcia-Parajo MF, Mayor S. Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane. Mol Biol Cell. 2019 Oct 2:mbcE18110715. doi: 10.1091/mbc.E18-11-0715. PubMed PMID: 31577524. (biorXiv preprint can be accessed here)
55. Ditlev JA, Vega AR, Köster DV, Su X, Tani T, Lakoduk AM, Vale RD, Mayor S, Jaqaman K, Rosen MK. A composition-dependent molecular clutch between T cell signaling condensates and actin. Elife. 2019 Jul 3;8. pii: e42695. doi:10.7554/eLife.42695. PubMed PMID: 31268421; PubMed Central PMCID: PMC6624021. (biorXiv preprint can be accessed here)
54. Kalappurakkal JM, Anilkumar AA, Patra C, van Zanten TS, Sheetz MP, Mayor S. Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains that Promote Cell Spreading. Cell. 2019 May 16. pii: S0092-8674(19)30456-8. doi: 10.1016/j.cell.2019.04.037. [Epub ahead of print] PubMed PMID: 31104842. (biorXiv preprint can be accessed here)

53. Thottacherry JJ, Kosmalska AJ, Kumar A, Vishen AS, Elosegui-Artola A, Pradhan S, Sharma S, Singh PP, Guadamillas MC, Chaudhary N, Vishwakarma R, Trepat X, Del Pozo MA, Parton RG, Rao M, Pullarkat P, Roca-Cusachs P, Mayor S. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension inadherent cells. Nat Commun. 2018 Oct 11;9(1):4217. doi:10.1038/s41467-018-06738-5. PubMed PMID: 30310066. (biorXiv preprint can be accessed here)
52. Sathe M, Muthukrishnan G, Rae J, Disanza A, Thattai M, Scita G, Parton RG, Mayor S. Small GTPases and BAR domain proteins regulate branched actin polymerisation for clathrin and dynamin-independent endocytosis. Nat Commun. 2018 May 9;9(1):1835. doi: 10.1038/s41467-018-03955-w. PubMed PMID: 9743604. (biorXiv preprint can be accessed here)
51. Jha A, van Zanten TS, Philippe JM, Mayor S, Lecuit T. Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis. Curr Biol. 2018 Apr 25. pii: S0960-9822(18)30426-3. doi: 10.1016/j.cub.2018.03.068. PubMed PMID: 29731302.
50. Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi CR, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018 Jan 11;172(1-2):305-317.e10. doi: 10.1016/j.cell.2017.12.023. PubMed PMID: 29328918.

49. Nordenfelt P, Moore TI, Mehta SB, Kalappurakkal JM, Swaminathan V, Koga N, Lambert TJ, Baker D, Waters JC, Oldenbourg R, Tani T, Mayor S, Waterman CM, Springer TA. Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. Nat Commun. 2017 Dec 11;8(1):2047. doi: 10.1038/s41467-017-01848-y. PubMed PMID: 29229906; PubMed Central PMCID:PMC5725580.
48. Swaminathan V, Kalappurakkal JM, Mehta SB, Nordenfelt P, Moore TI, Koga N, Baker DA, Oldenbourg R, Tani T, Mayor S, Springer TA, Waterman CM. Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10648-10653. doi:10.1073/pnas.1701136114. PubMed PMID: 29073038; PubMed Central PMCID: PMC5635867.
47. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006. PubMed PMID: 28340336.
46. Hemalatha A, Prabhakara C, Mayor S. Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling in Drosophila wing discs. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201610565. PubMed PMID: 27791132; PubMed Central PMCID: PMC5111669.
45. Köster DV, Husain K, Iljazi E, Bhat A, Bieling P, Mullins RD, Rao M, Mayor S. Actomyosin dynamics drive local membrane component organization in an in vitro active composite layer. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1645-54. doi: 10.1073/pnas.1514030113. Epub 2016 Feb 29. PubMed PMID: 26929326; PubMed Central PMCID: PMC4812753.

2011-2015

44. Parchure A, Vyas N, Ferguson C, Parton RG, Mayor S. Oligomerization and endocytosis of Hedgehog is necessary for its efficient exovesicular secretion. Mol Biol Cell. 2015 Oct 21. pii: mbc.E15-09-0671. PubMed PMID: 26490120.
43. Saha S, Lee IH, Polley A, Groves JT, Rao M, Mayor S. Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin. Mol Biol Cell. 2015 Sep 16. pii: mbc.E15-06-0397. PubMed PMID: 26378258.
42. Kosmalska AJ, Casares L, Elosegui-Artola A, Thottacherry JJ, Moreno-Vicente R, González-Tarragó V, del Pozo MÁ, Mayor S, Arroyo M, Navajas D, Trepat X, Gauthier NC, Roca-Cusachs P. Physical principles of membrane remodelling during cell mechanoadaptation. Nat Commun. 2015 Jun 15;6:7292. PubMed PMID: 26073653;
41. Raghupathy R, Anilkumar AA, Polley A, Singh PP, Yadav M, Johnson C, Suryawanshi S, Saikam V, Sawant SD, Panda A, Guo Z, Vishwakarma RA, Rao M, Mayor S. Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins. Cell. 2015 Apr 3;161(3):581-94. PubMed PMID: 25910209.
40. Baral A, Irani NG, Fujimoto M, Nakano A, Mayor S, Mathew MK. Salt-induced remodeling of spatially restricted clathrin-independent endocytic pathways in Arabidopsis root. Plant Cell. 2015 Apr;27(4):1297-315. Epub 2015 Apr 21. PubMed PMID: 25901088.
39. Shrivastava R, Köster D, Kalme S, Mayor S, Neerathilingam M. Tailor-made ezrin actin binding domain to probe its interaction with actin in-vitro. PLoS One. 2015 Apr 10;10(4):e0123428 PubMed PMID: 25860910.
38. Lee IH, Saha S, Polley A, Huang H, Mayor S, Rao M, Groves JT. Live cell plasma membranes do not exhibit a miscibility phase transition over a wide range of temperatures. J Phys Chem B. 2015 Mar 26;119(12):4450-9. Epub 2015 Mar 18. PubMed PMID: 25747462.

37. Polley A, Mayor S, Rao M. Bilayer registry in a multicomponent asymmetric membrane: dependence on lipid composition and chain length. J Chem Phys. 2014 Aug 14;141(6):064903. PubMed PMID: 25134595
36. Gupta GD, Dey G, Mg S, Ramalingam B, Shameer K, Thottacherry JJ, Kalappurakkal JM, Howes MT, Chandran R, Das A, Menon S, Parton RG, Sowdhamini R, Thattai M, Mayor S. Population Distribution Analyses Reveal a Hierarchy of Molecular Players Underlying Parallel Endocytic Pathways. PLoS One. 2014 Jun 27;9(6):e100554. doi: 10.1371/journal.pone.0100554.
35. Manzo C, van Zanten TS, Saha S, Torreno-PinaA, Mayor S, Garcia-Parajo MF. PSF decomposition of nanoscopy images via Bayesian analysis unravels distinct molecular organization of the cell membrane. Sci Rep. 2014 Mar 12;4:4354. doi:10.1038/srep04354. PubMed PMID: 24619088.
34. Dey G, Gupta GD, Ramalingam B, Sathe M, Mayor S, Thattai M. Exploiting cell-to-cell variability to detect cellular perturbations. PLoS One. 2014 Mar 4;9(3):e90540.
33. Yadav M, Raghupathy R, Saikam V, Dara S, Singh PP, Sawant SD, Mayor S, Vishwakarma RA.Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchor. Org Biomol Chem. 2014 Jan

32. Saha R, Verma PK, Rakshit S, Saha S, Mayor S, Pal SK. Light driven ultrafast electron transfer in oxidative redding of Green Fluorescent Proteins. Sci Rep.2013 Apr 3;3:158
31. Pols MS, van Meel E, Oorschot V, Ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J. (2013) hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Nat Commun. 2013 Jan 15;4:1361
30. Gowrishankar K, Ghosh S, Saha S, C R, Mayor S, Rao M. (2012) Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules, Cell.149(6):1353-67. (Also See: Ivo F. Sbalzarini, Active Flows Cluster Cell Surface Proteins, Developmental Cell, 22, 1121-1122 (2012).
29. Chaudhuri A, Bhattacharya B, Gowrishankar K, Mayor S, Rao M. (2011) Spatiotemporal regulation of chemical reactions by active cytoskeletal remodeling, Proc Natl Acad Sci U S A.108(36):14825-30.
28. Swetha MG, Sriram V, Krishnan KS, Oorschot VM, ten Brink C, Klumperman J, Mayor S. (2011) Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells. Traffic.12(8):1037-55.

2005-2010

27. Carvalho M, Schwudke D, Sampaio JL, Palm W, Riezman I, Dey G, Gupta GD, Mayor S, Riezman H, Shevchenko A, Kurzchalia TV, Eaton S. (2010) Survival strategies of a sterol auxotroph, Development.137(21):3675-85.
26. Howes MT, Kirkham M, Riches J, Cortese K, Walser PJ, Simpson F, Hill MM, Jones A, Lundmark R, Lindsay MR, Hernandez-Deviez DJ, Hadzic G, McCluskey A, Bashir R, Liu L, Pilch P, McMahon H, Robinson PJ, Hancock JF, Mayor S, Parton RG.(2010) Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol.190(4):675-91.
25. Gupta, G.D., Swetha, M.G., Kumari, S., Lakshminarayan, R., Dey, G. and Mayor, S. (2009). Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. PLoS One, 4, e6768.
24. Chaudhry A, Verghese DA, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S.(2009) HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway. J Immunol.183(4):2415-24.
23. Modi, S., Swetha, M. G., Goswami, D., Gupta, G. D., Mayor, S. and Krishnan, Y. (2009). A DNA nanomachine that maps spatial and temporal pH changes in living cells. Nature Nanotechnology, 4, 325–330.
22. Goswami D, Gowrishankar K, Bilgrami S, Ghosh S, Raghupathy R, Chadda R, Vishwakarma R, Rao M, Mayor S. Nanoclusters of GPI-anchored proteins are formed by cortical actin-driven activity. Cell.135(6):1085-97.
21. Chaudhry A, Das SR, Jameel S, George A, Bal V, Mayor S, Rath S.(2008) HIV-1 Nef induces a Rab11-dependent routing of endocytosed immune costimulatory proteins CD80 and CD86 to the Golgi. Traffic.9(11):1925-35.
20. Kumari S, Borroni V, Chaudhry A, Chanda B, Massol R, Mayor S, Barrantes FJ.(2008) Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway. J Cell Biol.181(7):1179-93.
19. Vyas N, Goswami D, Manonmani A, Sharma P, Ranganath HA, VijayRaghavan K, Shashidhara LS, Sowdhamini R, Mayor S.(2008) Nanoscale organization of hedgehog is essential for long-range signaling. Cell;133(7):1214-27. (Also See: Vincent JP. Hedgehog nanopackages ready for dispatch. Cell.133(7):1139-41)
18. Chandra V, Kar-Roy A, Kumari S, Mayor S, Jameel S, (2008) The HEV ORF3 protein modulates EGFR trafficking, STAT3 translocation and the acute phase response, J Virol.82(14):7100-10.
17. Kumari S, Mayor S. (2008) ARF1 is directly involved in dynamin-independent endocytosis, Nat Cell Biol, 10(1):30-41.
16. Chaudhary A, Das SR, Jameel S, George A, Bal V, Mayor S and Rath S. (2007) A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86, Cell Host Microbe, 1(1):37-49.
15. Altman D, Goswami D, Hasson T, Spudich JA, Mayor S. (2007) Precise positioning of myosin VI on endocytic vesicles in vivo, PLoS Biol, 5(8):e210.
14. Chadda R, Howes MT, Plowman SJ, Hancock JF, Parton RG, Mayor S. (2007) Cholesterol-sensitive Cdc42 activation regulates actin polymerization for endocytosis via the GEEC pathway, Traffic, 8(6):702-17.
13. Sarasji RC, Mayor S, Rao M. (2007) Chirality-induced budding: a raft-mediated mechanism for endocytosis and morphology of caveolae, Biophys J., 92(9):3140-58.
12. Kalia M, Kumari S, Chadda R, Hill MM, Parton RG, Mayor S. (2006) Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery
11. Rajagopal D, Bal V, Mayor S, George A, Rath S. (2006) A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules, Eur J Immunol, 36(4):828-41.
10. Chaudhary A, Das SR, Hussain A, Mayor S, George A, Bal V, Jameel S, Rath S. (2005) The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs, J Immunol, 175(7):4566-74.
9. Kirkham M, Fujita A, Chadda R, Nixon SJ, Kurzchalia TV, Sharma DK, Pagano RE, Hancock JF, Mayor S, Parton RG. (2005) Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles, J Cell Biol, 68(3):465-76.

1998-2005

8. Dani A, Chaudhary A, Mukherjee P, Rajagopal D, Bhatia S, George A, Bal V, Rath S, Mayor S. (2004) The pathway for MHCII-mediated presentation of endogenous proteins involves peptide transport to the endo-lysosomal compartment, J Cell Sci, 15;117(Pt 18):4219-30.
7. Sharma P, Varma R, Sarasji RC, Ira, Gousset K, Krishnamoorthy G, Rao M, Mayor S. (2004) Nanoscale organization of multiple GPI-anchored proteins in living cell membranes, Cell, 116(4):577-89.
6. Guha A, Sriram V, Krishnan KS and Mayor S. (2003). Shibire mutations reveal distinct dynamin-independent and -dependent endocytic pathways in primary cultures of Drosophila hemocytes. J Cell Sci 116, 3373-3386.
5. Sriram V, Krishnan KS and Mayor S. (2003). Deep-orange and carnation define distinct stages in late endosomal biogenesis in Drosophila melanogaster. J Cell Biol 161, 593-607.
4. Sabharanjak S, Sharma P, Parton RG and Mayor S. (2002). GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway. Dev Cell 2, 411-423.
3. Chatterjee S, Smith ER, Hanada K, Stevens VL and Mayor S. (2001). GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment. Embo J 20, 1583-1592.
2. Varma R, Mayor S. (1998). GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394, 798-801.
1. Mayor S, Sabharanjak S, Maxfield FR (1998). Cholesterol-dependent retention of GPI-anchored proteins in endosomes. The EMBO Journal 17, 4626–4638.

Archive - Reviews, Comments and Chapters:

Parchure A, Vyas N, Mayor S. Wnt and Hedgehog: Secretion of Lipid-Modified Morphogens. Trends Cell Biol. 2017 Nov 10. pii: S0962-8924(17)30185-X. doi: 10.1016/j.tcb.2017.10.003. Review. PubMed PMID: 29132729.
Sezgin E, Levental I, Mayor S, Eggeling C. The mystery of membrane organization: composition, regulation and roles of lipid rafts. Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374. doi: 10.1038/nrm.2017.16. Epub 2017 Mar 30. Review. PubMed PMID: 28356571; PubMed Central PMCID: PMC5500228.
Köster DV, Mayor S. Cortical actin and the plasma membrane: inextricably intertwined. Curr Opin Cell Biol. 2016 Feb;38:81-9. doi:10.1016/j.ceb.2016.02.021. Epub 2016 Mar 15. Review. PubMed PMID: 26986983.
Mayor S. The shifting geography and language of cell biology. J Cell Biol. 2015 May 11;209(3):323-5. doi: 10.1083/jcb.201412146. PubMed PMID: 25963814;
Johannes L, Parton RG, Bassereau P, Mayor S. Building endocytic pits without clathrin. Nat Rev Mol Cell Biol. 2015 May;16(5):311-21. Epub 2015 Apr 10. PubMed PMID: 25857812.
Saha S, Anilkumar AA, Mayor S. GPI-anchored protein organization and dynamics at the cell surface. J Lipid Res. 2015 Sep 22. pii: jlr.R062885. PubMed PMID: 26394904.
Saha S, Raghupathy R, Mayor S. Homo-FRET imaging highlights the nanoscale organization of cell surface molecules. Methods Mol Biol. 2015;1251:151-73. PubMed PMID: 25391799.
Rao M, Mayor S. Active organization of membrane constituents in living cells. Curr Opin Cell Biol. 2014 Jun 26;29C:126-132. doi: 10.1016/j.ceb.2014.05.007. Review. PubMed PMID: 24975942
Mayor S, Parton RG, Donaldson JG. Clathrin-Independent Pathways of Endocytosis. Cold Spring Harb Perspect Biol. 2014 Jun 2;6(6)
Mayor S. (2013) Biological research in India. An interview with Dr Satyajit Mayor, Dean at the National Centre for Biological Sciences in Bangalore, India. Interview by Barbara Pauly. EMBO Rep Mar 1;14(3):239-41.
Brodsky FM, Thattai M, Mayor S. (2012) Evolutionary cell biology: Lessons from diversity. Nat Cell Biol. 14(7):651.
Ghosh S, Saha S, Goswami D, Bilgrami S, Mayor S. (2012) Dynamic imaging of homo-FRET in live cells by fluorescence anisotropy microscopy, Methods Enzymol,505:291-327.
Mayor S. (2011) Cell biology in India: the future needs an international perspective. Nat Cell Biol.13(12):1385.
Mayor S. (2011) Squishy matter and active chemistry: understanding membrane organization. Nat Cell Biol.13(5):519.
Mayor S.(2011) Need tension relief fast? Try caveolae, Cell.144(3):323-4.
Mayor S.(2010) Serendipity and cell biology, Mol Biol Cell.21(22):3807-8.
Tanaka KA, Suzuki KG, Shirai YM, Shibutani ST, Miyahara MS, Tsuboi H, Yahara M, Yoshimura A, Mayor S, Fujiwara TK, Kusumi A.(2010) Membrane molecules mobile even after chemical fixation. Nat Methods;7(11):865-6.
Johannes L, Mayor S.(2010) Induced domain formation in endocytic invagination, lipid sorting, and scission. Cell.142(4):507-10.
Howes MT, Mayor S, Parton RG. (2010) Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis, Curr Opin Cell Biol ;22(4):519-27.
Kumari S, Mg S, Mayor S. (2010) Endocytosis unplugged: multiple ways to enter the cell, Cell Res. 20(3):256-75.
Chadda R, Mayor S. (2008) PTRF triggers a cave in, Cell, 132(1):23-4.
Mayor S and Pagano RE. (2007) Pathways of clathrin-independent endocytosis, Nat Rev Mol Cell Biol, 8(8):603-12.
Malhotra V, Mayor S. (2006) Cell biology: the Golgi grows up, Nature, 441(7096):939-40.
Rao M, Mayor S. (2005) Use of Forster's resonance energy transfer microscopy to study lipid rafts, Biochim Biophys Acta, 1746(3):221-33.
Mayor S. (2005) ACEing GPI release, Nat Struct Mol Biol, 12(2):107-8.
Sabharanjak S, Mayor S. (2004). Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev 56, 1099-1109.
Mayor S, Riezman H. (2004) Sorting GPI-anchored proteins, Nat Rev Mol Cell Biol, 5(2):110-20.
Mayor S, Rao M. (2004) Rafts: scale-dependent, active lipid organization at the cell surface, Traffic, 5(4):231-40.
Sharma P, Sabharanjak S, Mayor S. (2002). Endocytosis of lipid rafts: an identity crisis. Semin Cell Dev Biol 13, 205-214.
Chatterjee S, Mayor S. (2001). The GPI-anchor and protein sorting. Cell Mol Life Sci 58, 1969-1987.
Zurzolo C, van Meer G, Mayor S. (2003). The order of rafts. Conference on microdomains, lipid rats and caveolae.
Mayor S. (1999). Analysis of the cell-surface distribution of GPI-anchored proteins. Methods Mol Biol 116, 23-36.

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Prof. Satyajit Mayor - Archive Publications