As a bridging postdoc fellow at NCBS, I sought to understand the domain-swapping mechanism as a robust strategy for protein assembly in diverse β-hairpin proteins and their application. I worked on the plant proteins Monellin and Ubiquitin to answer questions about domain-swapping through protein engineering and crystallography.
Currently I am working as a Postdoctoral Associate at Department of Pharmacology, Yale School of Medicine. My current study focuses on the structure and function relationship of proteins involved in inflammation and cancer. I am interested in developing a CXCR5 biotherapeutics by engineering CXCL13 chemokine to treat AITL (angioimmunoblastic T-cell lymphoma). In AITL, there is an indication that aberrant expression of CXCL13 may activate an autocrine feedback loop by binding to CXCR5, possibly contributing to their proliferation and survival.
![](https://www.ncbs.res.in/sites/default/files/lab-members/manjula.jpg)
Manjula Ramu
manjula dot ramu at yale dot edu
manjula dot iob at gmail dot com