Research Interest
Protein quality control during neurodegeneration

Amanjot Singh
amanjsingh at ncbs dot res dot in
Neurodegenerative diseases are characterized by the accumulation of protein aggregates that are formed due to mutant proteins which contain longer than usual poly-Q stretches. Such aggregates/granules have been shown to contain both molecular chaperones as well as components of the ubiquitin-proteasome system (UPS). However, not much is known as to how proteins belonging to these two families are involved in these granules. I am interested in the mechanistic details in which molecular chaperones and UPS are involved in the assembly/clearance of poly-Q granules in the cells.