Research
We are studying the modulation of fundamental host cellular pathways during Mtb infection. We apply a combination of chemical genetics, quantitative image analysis and high content screening tools together with conventional cell and molecular biological approaches to define and study this problem.
The specific projects are:
a) Modulation of host lysosomes during Mtb infection
b) Drivers of heterogeneity during Mtb infection
c) Mtb pathogenesis mechanisms in vivo